Adaptive response as a criterion for assessing individual human radiosensitivity. Review

Most studies of radioadaptive response (RAR) in vivo have revealed its effective induction both by chronic and single irradiation a human organism with low doses. The classical way the for-mation RAR on peripheral blood lymphocytes (PBL) was noted as occupationally irradiated personnel residents areas increased natural or man-made accidental high background radiation. In some studies, liquidators Chernobyl accident children liv-ing pollution zone showed phenomenon increasing radiosensitivity PBL. A comparative analysis influence two types radiation (gamma betta) close RBE comparable effectiveness to induce an adaptive PBL mode exposure long term. Evidence also obtained study DNA end-points chromosomal damage. experiment effect neutrophils elderly people (age 63-84 years) induced acute gamma-rays wide range doses (0.1; 0.25; 1; 4 10 Gy) greatest radioresistance their phagocytic lysosomal activity is shown. Gamma-rays at (0.1 stimulated formation extracellular traps vitro using activated pyrogen (Pyrogernalum). article presents mechanisms vivo. should be considered indispensable factor for assessing controlling individual radiosensitivity.